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One randomized placebo-controlled trial that assessed the effect of oral lipoic acid supplementation in 58 patients diagnosed with metabolic syndrome, a condition characterized by abnormal glucose and lipid metabolism, showed that flow-mediated vasodilation improved by 44% with 300 mg/day of lipoic acid for four weeks (66)

Measurable density improvement requires 16 to 24 weeks

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The Bcl-2/Bax ratio increased and cleaved caspase-3 levels dropped, indicating reduced apoptosis (Pyo et al., 2007)