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247 TGF-, which is largely produced by CAFs and immune cells, induces SMAD-mediated transcriptional programs that drive CSC plasticity and EMT and is known to enrich CSC populations in hepatocellular carcinoma

Proc Natl Acad Sci USA 94(5):19671972 Hess B, Kutzner C, Van Der Spoel D, Lindahl E (2008) GROMACS 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation

These substitutions suggest that the PRX4 genes of the species lacking SRX are at least somewhat susceptible to hyperoxidation, even if not to the same degree as PRX1-3