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SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

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Short-term centrally acting muscle relaxants (e.g., cyclobenzaprine, tizanidine, methocarbamol): May provide symptomatic relief for acute painful spasms, but evidence for long-term prevention is limited

The underlying mechanism might be that reduced KCC2 and NKCC1 ratios lead to the relatively slow maturation of neural circuitry