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Consistent with previous reports, participants with fusion-positive AML presented at a younger age of onset compared to those with NPM1 -mutant or MDS-related AML (Supplementary Table 1)

Importantly, along with an induction of HIF1, in SCD erythroblasts cultured in the absence of hemin, we detected a significantly decreased CBS expression under hypoxia compared to normoxia (Supplementary Fig

In the 48-week phase 2 trial published in the New England Journal of Medicine, retatrutide at the 12mg weekly dose produced an average body weight reduction of 24.2%

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