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Abstract The introduction of the highly potent incretin receptor agonists semaglutide and tirzepatide has marked a new era in the treatment of type 2 diabetes and obesity

Although current treatments focus on reestablishing perfusion, they offer limited protection against the secondary ROS-mediated injury

Muscle preservation requires active attention Deeper weight loss creates risk of significant lean mass loss

Most gut peptide research has been conducted in rodent models, and while the mechanistic data is compelling, translation to human outcomes has not been established through large clinical trials