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These reactive molecules can damage cellular components, such as DNA, proteins, and lipids, leading to cellular dysfunction and death ( Increased ROS production is a common feature of chemotherapy-induced neurotoxicity (Was et al., 2022)

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In the chondrocytes of the iron overload model, the levels of GPX4 and SLC7A11 within the antioxidant system were lower, whereas lipid peroxidation levels, indicated by 4-HNE, were higher, and their mitochondria exhibited characteristics similar to ferroptosis (175)