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This mechanism also improves insulin sensitivity and modulates energy homeostasis, contributing to fat loss and preservation of muscle mass during caloric restriction

It produces worse side effects, more discontinuations, and often slower progress because severe GI symptoms prevent adequate nutrition and hydration

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Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea

However, its important to note that oral B12 supplements may have lower absorption rates compared to injections, especially for individuals with digestive issues that hinder B12 absorption