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For a detailed guide on protecting muscle during GLP-1 therapy, see: Prevent Muscle Loss on GLP-1

Because retatrutide is administered as a weekly injection, meals do not need to be timed around the injection itself

However, any weight lost during a session is likely water weight from sweating

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Cook SF, King AD, van den Anker JN et al , Simultaneous quantification of acetaminophen and five acetaminophen metabolites in human plasma and urine by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: method validation and application to a neonatal pharmacokinetic study