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Furthermore, (Sugawara et al., 2002) stated that reactive oxygen species can also inactivate thyroid peroxidase enzyme via two mechanisms, reversible formation of compound III due to excessive H 2 O 2 or O 2 , and irreversible free radical-mediated thyroid peroxidase (TPO) inactivation through attacking the active site of thyroid peroxidase enzyme, causing inactivation of the catalytic site of this enzyme resulting in disruption of the level of thyroid hormones

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