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To better characterize how retatrutide via the GCGR leads PCE, we studied drugs that have a bradycardic effect, namely, PIA and carbachol (Fig

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Phase 3 trials across larger and more diverse populations are required before any regulatory submission can be made

These findings have changed guidelines on T2D management over the last years, and GLP-1RAs are now widely used in overweight patients with T2D as well as in patients with T2D and cardiovascular disease regardless of glycaemic control