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That is the entire logic behind the slow, roughly four-week-per-step escalation ladder documented in the label and the trials: it trades a few extra weeks for dramatically better gastrointestinal tolerability

Allulose and GLP-1 Secretion: What In Vitro and Animal Studies Reveal In vitro and rodent studies suggest allulose may trigger GLP-1 secretion from intestinal L-cells more robustly than glucose, possibly by modulating sweet taste receptors (TAS1R2/TAS1R3) or metabolic sensors

This article was originally published on WBUR.org

doi: 10.1016/0041-008x(88)90040-3