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(1992) Identification of the active site residues in dipeptidyl peptidase IV by affinity labeling and site-directed mutagenesis

Different medical options produce different results, with weight loss probabilities ranging from 23.1% for nutrition counseling to 93.0% for bariatric surgery, and structured plans that may include meal replacement can lead to 15-30 kg of loss in 12-20 weeks

Rosmond R, Chagnon YC, Holm G, Chagnon M, Prusse L, Lindell K, et al

95% CI, 0.69-0.97)

The dominant adverse events in both are gastrointestinal nausea, diarrhea, vomiting, and constipation and in both they are dose-dependent and tend to ease as the body adapts to gradual dose escalation