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GLP-1 agonist benefits to consider For those who are at greater risk of cardiovascular issues, some of the GLP-1 receptor agonists have shown cardiovascular benefits or a neutral cardiovascular profile
The aggressive titration tail in the 12 mg arm of the Phase 2 trial was strongly associated with higher rates of transient gastrointestinal adverse events, which is why researchers generally favor slower escalation when tolerability is prioritized
Li M, Zhao S, Wu S, Yang X, Feng H
Published clinical trial data generally shows higher average weight loss with brand-name tirzepatide than with brand-name semaglutide in controlled conditions - approximately 20.9% body weight reduction with tirzepatide in the SURMOUNT-1 trial versus approximately 14.9% with semaglutide in the STEP-1 trial
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