Accumulating evidence suggests that the regulation of ferroptosis can change the level of OS in cardiomyocytes or vascular cells, resulting in cardiomyocyte injury, cardiac hypertrophy and HF through the interaction between ROS with ERS ( In summary, CD is pivotal for internal homeostasis and prevention of CCVDs ( 3.3.4 Ferroptosis and Inflammation Inflammation is a basic pathological process including infection and tissue damage, and appears when the organism is stimulated by some specific physiological or pathological factors
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PINK1-Parkin-dependent mitophagy in cardiac stress and cardioprotection Among mitophagy pathways, the PINK1-Parkin axis is one of the best characterized (Fig
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Future studies should also take into account the potential influence of gender on iron metabolism and its participation in PD pathogenesis and progression
