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Its probable mechanism includes activation of renal AGE-RAGE signaling pathways, decreasing levels of monocyte chemotactic protein-1 (MCP-1) and PKC-A, which consequently reduces the production of slit diaphragm proteins such as nephrin and podocin, thereby mitigating the impact of AGE-mediated DN pathogenesis (Muthenna et al., 2014)

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It contains a trace amount of calories (less than 5 per serving), which can be displayed as zero calories on the label under the Food and Drug Administration (FDA) Code of Federal Regulations

Results and discussion Shape and particle size of powders and preparations of melanin Macroscopic and SEM images of melanin preparations are presented in Fig

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