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Tirzepatide# Tirzepatide is a 39-amino acid peptide with a C20 fatty diacid side chain that activates two receptors: GIP receptor : Tirzepatide shows approximately 5-fold selectivity for GIP over GLP-1 receptors, representing a GIP-dominant dual agonist GLP-1 receptor : Provides complementary glucose-lowering and appetite-suppressing effects The GIP receptor engagement is a key differentiator from pure GLP-1 agonists like semaglutide

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Diarrhea that has not improved after 4 weeks at a stable dose

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At lower doses, the total amount of circulating retatrutide between injections drops below the perceptible therapeutic threshold before the next dose replenishes it