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Furthermore, the constant stimulation of STN excitatory neurons (at 130180 Hz) may result in brain-derived neurotrophic factor (BDNF) release to STN and distant circuit targets, potentially exerting a significant neuroprotective effect 60,73

Collectively, these temporally coordinated and overlapping pathways form a self-reinforcing network that mitigates inflammation, restores proteostasis, and extends cellular lifespan