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Further clinical studies are needed to validate the causal relationship between prolactin and obesity, and to explore the specific mechanisms by which prolactin levels and rhythms are regulated to improve obesity and metabolic health

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The more frequent injection site reactions with exenatide once weekly (22%) compared with semaglutide (1.2%) in SUSTAIN-3 could be a consequence of this ( The head-to-head studies within the SUSTAIN and PIONEER programs allow some comparison of the adverse effect profile ( Table 2 )

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These medications mimic a naturally occurring hormone that helps regulate appetite, blood sugar, and digestion