Step 1: Consider Reducing Inflammation Here's Why This Is Important: Inflammation, triggered by declining estrogen levels, may intensify perimenopausal symptoms and could increase the risk of chronic diseases later in life
Several RCT investigated the role of liraglutide, alone or in combination with metformin, in women with PCOS and overweight or obesity, confirming its beneficial effect on anthropometric and metabolic features 95
The 2024 ADA and Obesity Society guidance both address this scenario directly
Variants in GIPR (the GIP receptor itself, including rs1800437), GLP1R (the GLP-1 receptor), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with different response patterns to tirzepatide and semaglutide
Inject as soon as you remember, even if it is nighttime