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IGF-I stimulates RANKL, ephrin B2 and EphB4 expression in osteoblasts and RANK and EphrinB2 expression in osteoclasts

Standard maintenance dosing ranges from 1000 mcg weekly to 1000 mcg monthly

Therefore, hypoxia acts as a factor that worsens (or is exacerbated by) lipotoxicity and, importantly, it could be a link between simple steatosis and NASH

doi: 10.1097/MIB.0000000000000955 65 Gomez-BrisRSaezAHerrero-FernandezBRiusCSanchez-MartinezHGonzalez-GranadoJM