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Synthesis Synthesis of Glutathione(GSH) occurs via a two-step ATP-requiring enzymatic process

ScirACianfrugliaLMinnelliCBartoliniDTorquatoPPrincipatoGet alGlutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways

In fact, in liver, an organ in which glutathione synthesis is most active, the degradation is very slow due to the very low activity of -glutamyl transpeptidase

Clahsen PC, Moison RM, Holtzer CA, Berger HM