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Within this context, the gut microbiota can be considered a potential component of this integrated system, given its involvement in enteroendocrine and incretin signaling

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The adverse psychiatric events were observed in 26% of the participants in the rimonabant group compared with 14% in the placebo group in the same 4 studies [22], and the risk of depressive symptoms was estimated at 2.5 fold higher than in placebo-treated patients [8]