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Another B12 shot side effect is diarrhea, though its usually pretty mild

That said, signs or symptoms that you may be low in vitamin B12 include: fatigue pale skin headaches symptoms of depression stomach issues difficulty focusing or concentrating pain or inflammation in the mouth or on the tongue burning or pins and needles feeling in your hands or feet muscle cramps vision changes Learn more: Signs and symptoms of B12 deficiency

Cons: Digestive Sensitivity: For some individuals, taking glutathione on an empty stomach may cause discomfort or digestive upset

Retatrutide is more aggressive mechanistically