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8,9 Generally, released GLP-1 from intestinal L cells bind onto canonical receptors in the pancreatic islet, after oral glucose load, or may indirectly signal the hepatic vagal branch within intraportal vein, thereby promoting glucose-dependent insulin secretion from the pancreatic -cells, concurrently causing inhibition of glucagon secretion, and enhancing insulin gene transcription

& Abdelghany, R