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Key advances In the SURMOUNT-1 trial for obesity, adults with overweight or obesity without type 2 diabetes mellitus achieved placebo-subtracted weight loss of up to 20% after 72 weeks of the GLP1GIP receptor co-agonist tirzepatide, with a similar safety profile to high-dose semaglutide 5

On the other hand, Akkermansia muciniphila can activate immune cells in the intestine, such as macrophages and dendritic cells, to secrete the anti-inflammatory cytokine IL-10 and inhibit the inflammatory response (Mei et al., 2024)

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A GLP-1-optimized diet supports treatment by reducing nausea and maintaining digestive health alongside medication

Type 2 Diabetes: Semaglutide for Cardiovascular Risk Reduction