hdl:10665/44053
Criteria used to exclude ineligible papers were: studies published in language other than English, comments, personal opinions, old data, not relevant to the topic, no quantifiable evidence, non-relevant population and outcome
the use of pro-GSH molecules (Fraternale et al., 2006) and/or glutathione precursors like N-acetyl cysteine (NAC), glutamine, cysteine (cystine) and glycine, as well as nuclear factor erythroid 2 p45related factor 2 (Nrf2) inducers like sulforaphane can enhance glutathione production and increase nuclear Nrf2 translocation and antioxidant response element (ARE) transcription (Komaravelli and Casola, 2014
We believe that FDA approval of this treatment helps not only a subset of NF1 patients, it opens the door to increased interest in all forms of NF by pharmaceutical companies
Amino Acids 41, 159171, 10.1007/s00726-010-0571-x (2011)