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It plays multiple roles, including detoxification, protecting cells from oxidative stress, and supporting immune function

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Due to its hydrophobicity, quercetin has relatively poor solubility in water (0.177 g/ml), gastric fluids (5.5 g/ml) and small intestine fluids (28.9 g/ml), which have reduced its bio-accessibility ( Quercetin can be transported through sodium-dependent glucose transporter 1(SGLT1)

The authors also searched the ClinicalTrials.gov ( and the International Clinical Trials Registry Platform ( to ensure that the search was comprehensive and to minimize publication bias

Other Nrf2-dependent genes, including GPX4, GSH and NADPH synthesis genes, as well as epigenetic regulators of lipid hydroperoxides, contribute to its ferroptosis-inhibitory effects (117119)