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With respect to glutathione S-transferases, they catalyze the conjugation of reduced glutathione to diverse compounds, enabling the detoxification of xenobiotic-derived substances, yet they can also activate oxidative metabolites with carcinogenic potential

A similar dynamics was observed in grk2 mutants (although the effect was less prominent), and in some of the eat16 and osm6 mutants (though not as consistent as observed in the tax6 mutant animals, Fig 3A and D and Appendix Fig S3E and I)

GLP-1 receptor agonists mimic the action of a hormone glucagon-like peptide 1 that the gut secretes after eating

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