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Jacqueline Maya, M.D., from Massachusetts General Hospital-Mass General Brigham in Boston, and colleagues conducted a retrospective cohort study of 149,790 singleton pregnancies delivered between June 1, 2016, and March 31, 2025, to compare weight gain and pregnancy outcomes with and without exposure to GLP-1 RAs before or during early pregnancy

These findings emphasize the clinical significance of the observed increase in HBV-DNA negative conversion rate in this study, and highlight the potential of this combination therapy to improve long-term outcomes

To enhance the practical applicability of this framework, future research should also address the heterogeneity in dosing, treatment duration, and patient phenotypes observed across existing studies

10.1042/bcj20160748 Biochem J

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