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Bioavailability is usually determined by calculating the respective plasma drug exposure assessed as the total area under the drug plasma concentration versus time curve (AUC) after oral and intravenous administration as: In general, determinants of oral drug bioavailability include fraction of dose absorbed in the gastrointestinal tract (GIT) and fraction of dose that escapes elimination by the intestinal tract, liver, and lung
This differs fundamentally from the chaotic, leaky vessels tumors create to sustain their growth
La technologie liposomale permet de le rendre liposoluble
doi: 10.1016/j.tem.2003.09.002 125 EvansJLMadduxBAGoldfineID
Meredith MJ, Reed DJ
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