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Commenters stated that removing this measure could lead to decreased vaccination rates among healthcare personnel, thereby increasing the risk of hospital-acquired infections and compromising patient safety for vulnerable patient populations, such as those who are immunocompromised, undergoing cancer treatment, or pregnant

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Regeneration of DNA and RNA Methylation functions are also necessary for the repair and regeneration of DNA and RNA, as the required purines and pyrimidines are formed by the methylation cycle