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However, it should be noted that a recent international consensus document to define renal progression outcomes indicates decreases of 30, 40, 50 or 57% of kidney function as possible surrogates for progression, depending on factors such as the rate of progression, the choice of initial eGFR starting point or the effect of interventions with acute consequences on eGFR.39 4

11 JVS mice also carry an OCTN2 gene mutation 11, 25 and display a severe carnitine deficiency and the accumulation of lipid droplets in various cells (hepatocytes, renal tubular epithelial cells, cardiac myocytes, and striated myocytes)

Pharmacological Reviews, 45(2), 234-249

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