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Contact your GP or healthcare provider within 24 hours if you experience: New or persistent abdominal pain in the right upper quadrant or epigastrium lasting more than a few hours Recurrent episodes of abdominal pain, particularly after meals Unexplained nausea and vomiting that differs from your usual GLP-1-related side effects Any yellowing of the skin or whites of the eyes Dark urine or pale-coloured stools Seek immediate medical attention (attend A&E or call 999) if you develop: Severe, unrelenting abdominal pain High fever (temperature above 38C) with abdominal pain Jaundice accompanied by confusion or drowsiness Signs of sepsis, including rapid heartbeat, rapid breathing, or feeling extremely unwell When gallbladder disease is suspected, initial investigations typically include blood tests (full blood count, urea and electrolytes, liver function tests, C-reactive protein, bilirubin, and serum lipase or amylase) and abdominal ultrasonography, which is the first-line imaging modality for detecting gallstones and assessing the gallbladder

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Tirzepatide, the GLP-1 in Zepbound and Mounjaro, contributed to Eli Lilly passing US$1 trillion in market capitalization on November 21, 2025 the first healthcare company in history to cross that threshold

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CSF IL-6 levels have been found to be decreased in PD patients with major depression in comparison with patients with major depression without PD in one study (Plhagen et al., 2010), while another 4 found higher CSF IL-6 in PD patients than in healthy controls (Blum-Degen et al., 1996a

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Bananas A quick source of carbs, potassium, and vitamin B6 to fuel your workout

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The mismatch is environmental, not behavioral

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