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The disruption of the outer blood-retinal barrier observed in DR patients and diabetic mouse models [62] can activate RPE cells, triggering the EMT process

Cycling Strategies for Long-Term Research: Rather than continuous long-term use, many research protocols use cycling strategies that involve periods of IGF1 LR3 use alternating with off-cycle periods

The most commonly studied doses range from 1mg to 8mg administered daily for 28 days

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