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Research, including the STEP 1 extension study with semaglutide, consistently shows that most people experience a return of appetite to pre-treatment levels within weeks of discontinuation

Cellerino A, Maffei L, Domenici L (1996)

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MtDNA mutations and oocyte senescence mtDNA mutations may result from several factors: damage due to environmental factors, ROS-induced damage, polymerase errors during DNA replication, dysfunction of the mtDNA repair system, impaired degradation mechanisms of damaged mtDNA, and age-related accumulation of mutations (as shown in Fig

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