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doi: 10.1210/jc.2015-3291 46

2B3-101 increased doxorubicin brain delivery by approximately 5 fold resulting in reduced brain tumor growth and improved survival in mice [42, 46]

moreover, increased GGT levels correlated with BMPR2 mutation, hemodynamic dysfunction, and poor outcomes in male patients with idiopathic pulmonary arterial hypertension [77]