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Short-term economic analyses, such as cost of control analyses, complement longer-term analyses and are useful to assess and easily compare the cost-effectiveness of multiple new treatments

Patients may stop taking GLP-1s prematurelyand in turn, not achieve lasting results

It is worth noting that our participants had a higher baseline BMI (mean 41.5 kg m 2 ) than in the STEP 1 trial (37.9 kg m 2 ), with some studies 24 showing that greater weight loss is observed with a higher baseline BMI, which may explain the greater %WL observed in our trial

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It is important to contextualise this risk: obesity itself is an independent risk factor for pancreatitis, as are conditions commonly associated with excess weight such as gallstones, hypertriglyceridaemia, and type 2 diabetes