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Maternal Immune Activation Therapeutics Maternal immune activation (MIA), or the initiation of inflammatory pathways during pregnancy, has been associated with the pathogenesis of neurodevelopmental disorders, including ASD [45,46,47]

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doi: 10.7326/0003-4819-141-11-200412070-00035 64

The therapeutic approach includes a synthetic diet with reduced BCAA content, and thiamin (10-1,000 mg/day) is supplemented to patients with mutations in the E2 subunit of the BCKDH complex (111)