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Mimics Exercise-Induced Mitochondrial Adaptations MOTS-c promotes mitochondrial biogenesis, increases endurance capacity, and mimics many of the beneficial effects of physical activity, even in sedentary subjects
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This in vitro alteration of tight junction permeability correlated with the mechanism of how PPI induced increase in tight junction permeability in vivo as PPI administration did not have a significant impact in mice lacking the myosin light chain kinase gene in the experimental colitis models (Nighot et al
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