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Gen Hosp Psychiatry

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In addition, the glutaminase inhibitor IPN60090 can be combined with CB839 in the treatment of Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML), and with increasing doses of CB839 and IPN60090, the levels of intracellular NADPH and NADP+ are reduced, thereby inhibiting the proliferation of MDS and AML cells [72]

Venipunctures were performed twice before treatment, separated by 9 weeks, and once posttreatment

Shown are membrane-bound hemichromes (panel A), complement C3c fragment (panel B) and autologous IgG (panel C) in ring-infected and non-infected GR-deficient RBCs from the index patient, brother (individual 2) and sister (individual 3) of index patient, and from normal GR-sufficient controls