Plasma and tissue GSH levels decline with age, while markers of oxidative damage increase, creating a "redox imbalance" implicated in the pathogenesis of age-related diseases [2][3][10][11]
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In some cases, activation is accomplished by snake Gla-containing enzymes that bind to the endothelium of human blood vessels and catalyze the conversion of procoagulant clotting factors into activated ones, leading to unwanted and potentially deadly clotting
Kretzmann NA, Fillmann H, Mauriz JL, Marroni CA, Marroni N, Gonzlez-Gallego J, Tun MJ (2008) Effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis
Thus, using the Gene Expression Profiling Interactive Analysis (GEPIA) database [20], we observed that SYNCRIP expression was significantly elevated in multiple tumor types, including GBM, compared with normal tissues (Figure S1A) [21]
