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In addition, some aspects of GLP-1 beyond weight loss, such as preclinical evidence on GLP-1 effects in directly modulating the hypothalamuspituitarygonadal axis, or the effects of GLP-1RA on clinical and biochemical expression of hyperandrogenism, still deserve a greater insight, especially in light of a possible therapeutic use in PCOS women independently of obesity

Whats surprising is the breadth and consistency of effect across all of these different substances. Al-Aly and his team compared the risk that people would be diagnosed with substance-use disorders related to alcohol, cannabis, cocaine, nicotine, opioids and others

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Together they established that the GLP-1 (7-37) synthesised by Mojsov encouraged the secretion of insulin in rat pancreatic islet cells