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Simultaneous GLP-1 receptor activation in the hypothalamus reduces appetite signaling by delaying ghrelin rebound and prolonging the elevation of satiety hormones like peptide YY (PYY) and cholecystokinin (CCK)

Persistent vomiting, inability to keep fluids down, severe abdominal pain, or extreme fatigue are not normal and should be evaluated

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The surgery can often be done with local anesthesia (medication that temporarily blocks pain in a small area of the body) or light sedation, rather than general anesthesia (medication that puts you in a sleep-like state)

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