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Antioxidant activity Numerous experiments have been done to assess the antioxidant activity of CGAs, both in vitro and in vivo (Cha et al., 2014

21 , e12991 (2020)

119 Conversely, at the N-terminal domain, a non-catalytic regulatory haem sensor negatively impacts the enzymatic activity of CBS upon reduction and completely inactivates the enzyme upon binding of nitric oxide or carbon monoxide

The trial, however, was flawed in several ways

REDEFINE 2: Efficacy in Type 2 Diabetes REDEFINE 2, announced in March 2025, addressed a distinct population: 1,206 adults with obesity or overweight and type 2 diabetes across 12 countries, randomised in a 3:1 ratio to CagriSema or placebo for 68 weeks