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10.1002/mnfr.201100741

For statins, which are taken once daily and work through sustained liver enzyme inhibition rather than peak plasma concentration, this timing shift is unlikely to produce a meaningful clinical effect

In addition, a 48-week phase 2b randomized, placebo-controlled trial (involving 293 adults with obesity and biopsy-confirmed MASH and fibrosis stage F1-F3) reported that once-weekly subcutaneous survodutide at doses of 2.4 mg, 4.8 mg, or 6.0 mg was superior to placebo for histological improvement in MASH without worsening of liver fibrosis, warranting further investigation in phase 3 trials (Sanyal et al., 2024[67])

Most injection-related discomfort is completely preventable through proper site selection, rotation, and clean technique