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554 Relatively modest manipulation of gene expression using normal alleles may be sufficient to mitigate the effects of deleterious mutations

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2008 Apr;121(4):14141420

The albumin quotient (Q alb ), a key marker of BBB permeability, has been found to be elevated in several studies involving individuals with preclinical AD, mild cognitive impairment (MCI), and established AD itself (Halliday et al