During 72 weeks of treatment, people taking tirzepatide at doses of 5, 10, or 15 mg lost an average of 15.0%, 19.5%, and 20.9%, respectively, compared with just 3.1% in people taking a placebo
However, patients should be cautioned that exercise capacity may be temporarily reduced during the initial treatment period, and expectations should be adjusted accordingly
This distribution suggests GIP influences metabolism through somewhat different pathways than GLP-1, even though both are incretin hormones
The rationale for B12 inclusion is identical, though semaglutide lacks the GIP receptor component
The prevalence of T2DM is predicted to rise by 46% globally by 2045, suggesting that this issue becomes even more ominous as time progresses