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All chronic diseases, including COVID-19 with the long-COVID-19-syndrome (271), are characterized by the presence of persistent chronic inflammation and sustained generation of reactive oxygen and nitrogen species that when confronted with inadequate antioxidant defenses (likely leading components of anti-inflammaging) precipitate excessive oxidative stress

The cysteinylglycine dipeptide can also be taken up by cells in a process mediated by the peptide transporter 2, before being degraded in the cytoplasm by unspecific dipeptidases, 96 although the circumstances under which this occurs remain undetermined

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At neutral pH, these residues lose their charge, molecules attract each other, and you get aggregation