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In some cases, significant weight loss and energy deficit can lead to functional hypothalamic amenorrhoea, where the brain temporarily reduces signals to the ovaries

Petucci, C

Immunol Today, 18: 127-135

Ischemic cells compensate for reduced oxygen delivery by increasing anaerobic glycolysis, leading to acidosis as well as glucose derivatives that promote signaling related to oxidative stress and inflammation [38, 57, 62]

"Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure." Journal of Clinical Endocrinology & Metabolism 83.2 (1998): 362-369