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A meta-analysis in Scandinavian Journal of Medicine and Science in Sports confirmed that energy deficiency impairs resistance training gains in lean mass, and that individuals performing resistance training to preserve lean mass during weight loss should avoid energy deficits greater than 500 kcal/day (Murphy & Koehler, Scand J Med Sci Sports, 2022)
When you are losing weight rapidly and trying to preserve muscle, protein intake becomes non-negotiable
Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine